Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

1. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors

Michael T. Klein, Paige N. Vinson and Colleen M. Niswender

2. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders

Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender

3. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery

Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis

4. G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design

Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri

5. GPCRs in Stem Cell Function

Van A. Doze and Dianne M. Perez

6. Application of Receptor Theory to Allosteric Modulation of Receptors

David A. Hall

7. What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors

Frederick J. Ehlert

8. Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors

Jesús Giraldo

9. Chemokine Receptor Oligomerization and Allostery

Bryan Stephens and Tracy M. Handel

10. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac