Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research.

Covers reviews of methodology and research in all aspects of protein chemistryBrings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

1. Next Generation Sequencing Methodologies - An Overview

William O. Pickrell, Mark I. Rees and Seo-Kyung Chung

2. Next Generation Sequencing in the Clinical Domain: Clinical Advantages, Practical and Ethical Challenges

Rose Thompson, Cheney J. G. Drew and Rhys H. Thomas

3. Opportunities and Challenges for Genome Sequencing in the Clinic

Gianpiero L. Cavalleri and Norman Delanty

4. Polymorphisms in Neuropsychiatric and Neuroinflammatory Disorders and the Role of Next Generation Sequencing in Early Diagnosis and Treatment

Rossen M. Donev and Owain W. Howell

5. Structural Modelling Pipelines in Next Generation Sequencing Projects Jonathan G.L. Mullins