Epigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical Impact

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.

Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.

Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.

BMA Medical Book Awards 2014 - Highly Commended,  Neurology, British Medical AssociationBMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American PublishersPresents a unified view of epigenetic mechanisms from behavior to genes and everything in betweenDiscusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientistsProvides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

1. An Overview of the Molecular Basis of Epigenetics J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian

2. Histone modifications in the nervous system and neuropsychiatric disorders Morgan Bridi and Edwin "Ted" Abel

3. Active DNA Demethylation and 5-Hydroxymethylcytosine Junjie U. Guo, Guo-li Ming and Hongjun Song

4. Maternal Behavior Tie Yuan Zhang, Christian Caldji, Josie C. Diorio, Sabine Dhir, Gustavo Turecki, and Michael J. Meaney

5. Epigenetic Mechanisms in Learning and Memory Jeremy J. Day and J. David Sweatt

6. Drug Addiction and Reward Alfred J. Robison, Jian Feng, and Eric J. Nestler

7. The Mind and its Nucleosomes – Chromatin (dys)regulation in Major Psychiatric Disease Rahul Bharadwaj,  Cyril J. Peter, and Schahram Akbarian

8. HDAC inhibitors as novel therapeutics in Aging, and Alzheimer's disease Alexi Nott, Daniel M. Fass, Stephen J. Haggarty, and Li-Huei Tsai

9. Cell Differentiation in the CNS, Neuronal Fate Determination, and Development Yi Eve Sun

10. Imprinting in the CNS and Neurodevelopmental Disorders Weston T. Powell and Janine LaSalle

11. Neuronal Genomic and Epigenetic Diversity Michael J. McConnell and Fred H. Gage

12. Adult Neurogenesis Jenny Hsieh, Hongjun Song

13. Transgenerational Inheritance in Mammals Isabelle M. Mansuy, Rahia Mashoodh and Francis A. Champagne

14. Open Questions and Future Approaches in Neuroepigenetics J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian