Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field.

Provides a background to translational research and the use of brain imaging in neuropsychiatric disordersCritical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkersIdentifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders

Preface

Chapter 1: Neuroimaging Modalities: Description, Comparisons, Strengths and Weaknesses

Chapter 2: Magnetic Resonance Imaging as a Tool for Modelling Drug Treatment of CNS Disorders: Strengths and Weaknesses

Chapter 3: Small Animal Imaging as a Tool For Modelling CNS disorders: Strengths and Weaknesses

Chapter 4: Structural Magnetic Resonance Imaging as a Biomarker for the Diagnosis, Progression, and Treatment of Alzheimer’s Disease

Chapter 5: Positron Emission Tomography in Alzheimer’s disease: Diagnosis and Use as Biomarker Endpoints

Chapter 6: Rethinking the Contribution of Neuroimaging to Translation in Schizophrenia.

Chapter 7: Neuroimaging as a Translational Tool in Animal and Human Models of Schizophrenia

Chapter 8: Functional Magnetic Resonance Imaging as a Biomarker for the Diagnosis, Progression and Treatment of Autistic Spectrum Disorders

Chapter 9: Translational Neuroimaging for Drug Discovery and Development in Autism Spectrum Disorders: Guidance from Clinical Imaging and Preclinical Research

Chapter 10: Neuroimaging as a Biomarker for the Diagnosis, Progression and Treatment of Substance Abuse Disorder

Chapter 11: Translational Neuroimaging: Substance Abuse Disorders

Chapter 12: Neuroimaging Approaches to the Understanding of Depression and the Identification of Novel Antidepressants