Fidelity and Quality Control in Gene Expression

The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting.

Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translationSpecial attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting

1. Quality Control in Aminoacyl-tRNA Synthesis: Its Role in Translational Fidelity Srujana S. Yadavalli and Michael Ibba
2. Termination and Post-Termination Events in Eukaryotic Translation

Richard J. Jackson, Christopher U.T. Hellen and Tatyana V. Pestova

3. Quality Control of mRNA Decoding on the Bacterial Ribosome

Marina V. Rodnina

4. Control of Gene Expression by Translational Recoding

Jonathan D. Dinman

5. The tmRNA Ribosome Rescue System

Brian D. Janssen and Christopher S. Hayes

6. Posttranscriptional Recoding by RNA Editing Stefan Maas