Human Population Genetics and Genomics

Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools.

In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed.

Comprehensively explains the use of population genetics and genomics in medical applications and research Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposalsProvides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now

1. Definition, Scope and Premises of Human Population Genetics 2. The Human Genome 3. Systems of Mating 4. Genetic Drift 5. A Backwards View of Genetic Drift: Coalescence 6. Gene Flow and Subdivided Populations 7. Human Population History Over the Last Two Million Years 8. Genotype and Phenotype 9. Natural Selection 10. Detecting Selection Through its Interactions with other Evolutionary Forces 11. Units and Targets of Natural Selection 12. Human Adaptations to Temporally and Spatially Variable Environments 13. Selection in Age-Structured Populations 14. Human Population Genetics/Genomics and Society