Handbook of Systems Biology: Concepts and Insights

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics.

2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplinesIncludes the latest research developments in human and animal models to assist with translational researchPresents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

SECTION I: Component of biological systems Proteomic analysis of cellular systems The protein-coding transcriptome ncRNAs and their targets

SECTION II: Network properties of biological systems Probabilistic functional networks Protein-protein inteactome networks Gene regulatory networks Phenotypic profiling networks Genetic interaction networks Chromatin networks Drug-target networks Graph theory properties of cellular networks

SECTION III: Dynamic and logical propoerties of biological systems Boolean models of cellular networks Bayesian approaches in understanding networks Transcriptional network logic in development Metabolic systems reconstruction Evolution of biological networks Systems understanding of the cell cycle Quantitative design principles on molecular systems Systems biology of signaling Single cell systems dynamics Spatial organization of cellular systems

SECTION IV: Systems and biology Systems understanding of yeast biology systems understandingof c.elegans development Biological systems in Arabidopsis Biological rhythms in development and hemeostasis System biology of stem cells The brain connectome

SECTION V:MULTISCALE BIOLOGICAL SYSTEMS, HEALTH AND ECOLOGY Systems medicine Cancer systems biology Infectious disease and the immune system Network perturbations and disease states Impact of personal genomics on systems biology Social networks, human disease, and epidemics