Translating Mechanisms of Orofacial Neurological Disorder: From the Peripheral Nervous System to the Cerebral Cortex

In this volume, members of the International Translational Research Network on Orofacial Neurological Disorders and invited experts provide authoritative overviews of new aspects of motor function and sensation relating to neurological disorders in orofacial regions. Orofacial movements constitute fundamental motor patterns with essential roles in consummatory behavior, self-care, defensive and attack behaviors, vocalization and, in higher mammals, verbal as well as non-verbal communication. Clinically, dysfunction in orofacial movement is evident in numerous dental, cranio-maxillo-facial and neuropsychiatric disorders, including dysphagia, Huntington's disease, Parkinson's disease and schizophrenia.

Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

1. Behavioural Pharmacology of Orofacial Movement Disorder

Noriaki Koshikawa, Satoshi Fujita, Kazunori Adachi

2 Regulation of Orofacial Movement: Dopamine Receptor Mechanisms and Mutant Models

John L. Waddington, Gerard J. O’Sullivan and Katsunori Tomiyama

3 Regulation of Orofacial Movement: Amino Acid Mechanisms and Mutant Models

Katsunori Tomiyam, Colm M. P. O’Tuathaigh⁴ and John L. Waddington³

4 The Trigeminal Circuits Responsible for Chewing

Karl-Gunnar Westberg, and Arlette Kolta

5 Ultrastructural Basis for Craniofacial Sensory Processing in the Brainstem

Yong Chul Bae, Atsushi Yoshida

6 Mechanisms of Nociceptive Transduction and Transmission: A Mashinery for Pain Sensation and Tools for Selective Analgesia.

Alexander M. Binshtok

7 Peripheral and central mechanisms of orofacial Inflammatory pain

Barry J. Sessle

8 The Role of Trigeminal Interpolaris-Caudalis Transition Zone in Persistent Orofacial Pain

Ke Ren and Ronald Dubner

9 Physiological Mechanisms of Neuropathic Pain: The Orofacial Region

Koichi Iwata, Yoshiki Imamura, Kuniya Honda1, and Masamichi Shinoda

10 Neurobiology of Estrogen Status in Deep Craniofacial Pain

David A Bereiter and Keiichiro Okamoto

11 Macroscopic Connection of Rat Insular Cortex: Anatomical Bases Underlying Its Physiological Functions

Masayuki Kobayashi

12 The Balance between Excitation and Inhibition and Functional Sensory Processing in the Somatosensory Cortex

Zhi Zhang and Qian-Quan Sun