Molecular Biology of Cancer: Translation to the Clinic

Advances in molecular biology over the last several decades are being steadily applied to our understanding of the molecular biology of cancer, and these advances in knowledge are being translated into the clinical practice of oncology. This volume explores some of the most exciting recent advances in basic research on the molecular biology of cancer and how this knowledge is leading to advances in the diagnosis, treatment, and prevention of cancer.

* This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

1. Introduction to the Molecular Biology of Cancer: Translation to the Clinic

Raymond W. Ruddon

2. Molecular Biology and Anti-cancer Drug Discovery

John S. Lazo

3. Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic

Jian Zhang, Lalit Patel, and Kenneth J. Pienta

4. Chromosome Translocations in Solid Tumors

Arul Chinnaiyan and Nallasivam Palanisamy

5. Circulating Tumor Cells

Daniel F. Hayes and Jeffrey B. Smerage

6. Stem Cells in Normal Development and Cancer

Rosemarie Chirco D’Angelo and Max S. Wicha

7. Bioinformatics and Systems Biology of Cancers

Gilbert S. Omenn

8. Progress in Cancer Nanotechnology

James R. Baker, Istvan J. Majoros, Brent B. Ward, Kyung-Hoon Lee, Seok Ki Choi, Baohua Huang, Andrzej Myc

9. Applications of Molecular Imaging

Craig J. Galbán, Stefanie Galbán, Marcian E. Van Dort, Gary D. Luker, Mahaveer S. Bhojani, Alnawaz Rehemtualla and Brian D. Ross

10. Cancer epigenetic

Wendell Weber

11. Molecular Targets and Clinical Cancer Risk Reductive Interventions

Madhuri Kakarala and Dean E. Brenner