Pharmacology of 5-HT6 receptors, Part I

The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors.

1. 5-HT₆ Medicinal Chemistry

Kevin G. Liu and Albert J. Robichaud

2. Patents

Nicolas Vincent Ruiz and Gloria Oranias

3. 5-HT₆ Receptor Charactertization

Teresa Riccioni

4. 5-HT₆ receptor signal transduction. Second Messenger Systems

Xavier Codony, Javier Burgueño, Maria Javier Ramírez, José Miguel Vela

5. Electrophysiology of 5-HT₆ Receptors

Annalisa Tassone, Graziella Madeo, Giuseppe Sciamanna, Antonio Pisani, and Paola Bonsi

6. Genetic Variations and Association

Massimo Gennarelli and Annamaria Cattaneo

7. Pharmacokinetics of 5-HT₆ Receptors Ligands

Angelo Mancinelli