Structure, Function and Regulation of TOR complexes from Yeasts to Mammals: Part A

Cell growth is highly regulated and is controlled by the TOR signaling network. Dysfunction of signaling pathways controlling cell growth results in cells of altered sizes and in turn causes developmental errors and a wide range of pathological conditions. An understanding of the TOR signaling network may lead to novel drugs for the treatment of, for example, cancer, diabetes, inflammation, muscle atrophy, learning disabilities, depression, obesity and aging.

There has been an explosion of knowledge in this area in recent years and this volume provides an in-depth review of our current knowledge of TOR complexes by the leaders in the field.

Chapter 1: TOR complexes: composition, structure and phosphorylation

Mike Hall

Chapter 2: Regulation of TOR signaling in mammals

Dudley W. Lamming and David Sabatini

Chapter 3: Rheb G-protein and activation of mTORC1

Fuyu Tamanoi

Chapter 4: Regulation of TOR Complex1 by amino acids through small GTPases

Joe Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Joseph Rapley, and Noriko Oshiro

Chapter 5: Rag GTPases in TORC1 activation and nutrient signaling

Li Li and Kun-Liang Guan

Chapter 6: Amino Acid Regulation of hVps34 and mTORC1 signaling

Pawan Gulati and George Thomas

Chapter 7: mTORC1 and cell cycle control

Chris Proud

Chapter 8: AGC Kinases in mTOR Signaling

Estela Jacinto

Chapter 9: TORC1 signaling in budding yeast

Robbie Loewith

Chapter 10: TORC2 and sphingolipid biosynthesis and signaling: Lessons from budding yeast

Ted Powers

Chapter 11: TORC1 signaling in the budding yeast endomembrane system and control of cell-cell adhesion in pathogenic fungi

Robert J. Bastidas and Maria Cardenas-Corona

Chapter 12: TOR and sexual development in fission yeast

Yoko Otsubo and Masayuki Yamamoto

Chapter 13: Fission yeast TOR and rapamycin

Ronit Weisman

Chapter 14: Structure of TOR complexes in fission yeast

Junko Kanoh and Mitsuhiro Yanagida

Chapter 15: The TOR complex and signaling pathway in plants

Christophe Robaglia, Bruce Veit and Christian Meyer

Chapter 16: Dysregulation of TOR Signaling in Tuberous Sclerosis and Lymphangioleiomyomotosis

Elizabeth Henske

Chapter 17: Chemistry and Pharmacology of Rapamycin and its Derivatives

Robert T. Abraham, James J. Gibbons and Edmund I. Graziani