Development of T Cell Immunity

T cells belong to a group of white blood cells called lymphocytes and play a large role in the immune response. An increased understanding of T cell immunity will provide new insights into the etiology of human autoimmune disease such as diabetes.

This volume reviews the latest developments and discusses the evolution of T cell immunity, thymic requirements, and how to prevent T cell-dependent autoimmunity.

Development of T cell immunity

1. The development of T cell immunity – Adrian Liston

The evolution of T cell immunity

2. Genome duplication and T cell immunity – Masanori Kasahara

• Questions arising from "Genome duplication and T cell immunity" – Claude Perreault
• Response to questions – Masanori Kasahara

1. The origin and role of MHC class I-associated self peptides – Claude Perreault

• Questions arising from "The origin and role of MHC class I-associated self peptides" – Masanori Kasahara
• Response to questions – Claude Perreault

Thymic requirements for T cell immunity

1. Transcriptional regulation of thymus organogensis and thymic epithelial cell differentiation – Nancy Manley and Brian Condie
2. Early T cell differentiation: lessons from T-cell acute lymphoblastic leukemia – Cedric S Tremblay, Thu Hoang and Trang Hoang

T cell immunity in the periphery

3. Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses – Peter J L Lane, Fiona M McConnell, David Withers, Fabrina Gaspal, Manoj Saini and Graham Anderson

• Commentary on "Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses" – Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes

1. Cellular and Molecular Requirements in Lymph Node and Peyer’s Patch Development – Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes
2. T follicular helper cells during Immunity and Tolerance – Michelle A. Linterman and Carola G. Vinuesa

Preventing T cell-dependent autoimmunity

3. Thymic selection and lineage commitment of CD4⁺Foxp3⁺ regulatory T cells – Paola Romagnoli and Joost P.M. van Meerwijk
4. Molecular Mechanisms of Regulatory T cell Development and Suppressive Function – Jeong M. Kim

• Is Foxp3 the master regulator of regulatory T cells? – Adrian Liston