Structure and Function of Calcium Release Channels

This volume of Current Topics in Membranes focuses on Membrane Protein Crystallization, beginning with a review of past successes and general trends, then further discussing challenges of mebranes protein crystallization, cell free production of membrane proteins and novel lipids for membrane protein crystallization.

This publication also includes tools to enchance membrane protein crystallization, technique advancements, and crystallization strategies used for photosystem I and its complexes, establishing Membrane Protein Crystallization as a needed, practical reference for researchers.

PART 1: RyR Ca²⁺ Release channels

1. RyRs: their disposition, frequency and relationships with other proteins of calcium release units (Clara Franzini Armstrong).
2. Electron Microscopy of Ryanodine Receptors (Terrence Wagenknecht and Zheng Li).
3. The ryanodine receptor pore: is there a consensus view? (Carney, J; Mason, SA; Viero, CL and Williams, AJ)
4. Regulation of the RyR channel gating by different modulators (Derek Laver).
5. Regulation of Ryanodine Receptor Ion Channels through Post-translational Modifications. (Gerhard Meissner).
6. Crosstalk via the sarcoplasmic gap: The DHPR - RyR interaction (Manfred Grabner and Anamika Dayal).
7. Ryanodinopathies: RyR-linked Muscle Diseases (Lan Wei and Robert T. Dirksen).

PART 2: IP₃R Ca²⁺ Release channels

8. Structure of IP₃ Receptors. (Irina I. Serysheva and Steven J. Ludtke)
9. Molecular Architecture Of The Inositol 1,4,5-trisphosphate Receptor Pore. (Darren Boehninng)
10. Adenophostins: high-affinity agonists of IP₃ receptors. (Ana M. Rossi, Andrew, M. Riley, Barry V. L. Potter and Colin W. Taylor)
11. Regulation of IP₃R channel gating by Ca²⁺ and Ca²⁺ Binding Proteins (J. Kevin Foskett and Don-On Daniel Mak).
12. Regulation of IP₃R channels through phosphorylation/ATP (Matthew J. Betzenhauser and David I. Yule).
13. Role of thiols in the structure and function of Inositol trisphosphate receptors (Suresh Joseph).
14. Inositol 1,4,5-tripshosphate receptor, calcium signaling and polyglutamine expansion disorders (Ilya Bezprozvanny).