Enzyme Kinetics: Catalysis and Control: A Reference of Theory and Best-Practice Methods

Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes.

Historical analysis of kinetic principles including advanced enzyme scienceProvides both theoretical and practical measurements toolsCoverage of single molecular kineticsExamination of force generation mechanismsDiscussion of organic and inorganic enzyme reactions

 

1. An Introduction to Enzyme Rate Processes
2. Active Sites & Their Chemical Properties
3. Fundamentals of Chemical Kinetics
4. Practical Aspects of Measuring Rates & Kinetic
5. Initial-Rate Kinetics of One-Substrate Enzyme-Catalyzed Reactions
6. Initial-Rate Kinetics of Multi-Substrate Enzyme-Catalyzed Reactions
7. Other Factors Influencing Enzyme Activity
8. Kinetic Behavior of Enzyme Inhibitors
9. Isotopic Probes of Biological Catalysis
10. Probing Fast Enzyme Processes
11. Regulatory Behavior of Enzymes
12. Single-Molecule Enzyme Kinetics
13. Force Generation in Mechanoenzyme Catalysis
14. On Keeping a Research Notebook
15. Steady-State Rate Equations for Selected One- & Two-Substrate Enzyme-Catalyzed Reactions
16. Summary of Enzyme Kinetic Mechanisms Abbreviations & Symbols References