Notch Signaling

Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and in stem cells. This volume, which is part of the Current Topics in Developmental Biology series, covers topics such as Notch signaling in cardiac development and disease and Notch in stem cells. International authors provide researchers with an overview and synthesis of the latest research findings and contemporary thought in the area.

Covers topics such as Notch signaling in cardiac development and disease, and Notch in stem cellsInternational authors provide researchers with an overview and synthesis of the latest research findings and contemporary thought in the area

1. Notch: The Past The Present And The Future

- Spyros Artavanis-Tsakonas and Marc.A.T. Muskavitch

2. Mechanistic Insights Into Notch Receptor Signaling From Structural And Biochemical Studies

- Rhett A. Kovall And Stephen C. Blacklow

3. Canonical And Non-Canonical Notch Ligands

- Brendan D'souza, Laurence Meloty-Kapella, And Gerry Weinmaster

4. Roles Of Glycosylation In Notch Signaling

- Pamela Stanley And Tetsuya Okajim

5. Endocytosis And Intracellular Trafficking Of Notch And Its Ligands

- Shinya Yamamoto, Wu-Lin Charng And Hugo J Bellen

6. „-Secretase And The Intramembrane Proteolysis Of Notch - Ellen Jorissen And Bart De Strooper

7. Two Opposing Roles Of Rbp-J In Notch Signaling

- Kenji Tanigaki, Tasuku Honjo

8. Notch Targets And Their Regulation

- Sarah Bray And Fred Bernard

9. Notch Signaling In The Vasculature

- Thomas Gridley

10. Ultradian Oscillations In Notch Signaling Regulate Dynamic Biological Events

Ryoichiro Kageyama, Yasutaka Niwa, Hiromi Shimojo, Taeko Kobayashi, And Toshiyuki Ohtsuka

11. Notch Signaling In Cardiac Development And Disease Donal Macgrogan, Meritxell Nus & José Luis De La Pompa

12. Notch Signaling In The Regulation Of Stem Cell Self-Renewal And Differentiation

-Jianing Liu, Chihiro Sato, Massimiliano Cerletti, Amy Wagers

13. Notch Signaling In Solid Tumors 

- Ute Koch And Freddy Radtke

14. Non-Canonical Notch Signaling

- Pascal Heitzler