Organogenesis in Development

Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians.

Emphasizes up-to-date research relating to molecular control mechanisms

Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease

Distils common themes and differences for comparative studies

Highlights key remaining questions and sets the agenda for future research

1. How to Make a Heart: The Origin and Regulation of Cardiac

Progenitor Cells

Ste´phane D. Vincent and Margaret E. Buckingham

2. Vascular Development—Genetic Mechanisms and Links to

Vascular Disease

John C. Chappell and Victoria L. Bautch

3. Lung Organogenesis

David Warburton, Ahmed El-Hashash, Gianni Carraro, Caterina Tiozzo,

Frederic Sala, Orquidea Rogers, Stijn De Langhe, Paul J. Kemp,

Daniela Riccardi, John Torday, Saverio Bellusci, Wei Shi,

Sharon R Lubkin, and Edwin Jesudason

4. Transcriptional Networks and Signaling Pathways that Govern

Vertebrate Intestinal Development

Joan K. Heath

5. Kidney Development: Two Tales of Tubulogenesis

Melissa Little, Kylie Georgas, David Pennisi, and Lorine Wilkinson

6. The Game Plan: Cellular and Molecular Mechanisms of

Mammalian Testis Development

Elanor N. Wainwright and Dagmar Wilhelm

7. Building Pathways for Ovary Organogenesis in the

Mouse Embryo

Chia-Feng Liu, Chang Liu, and Humphrey H-C Yao

8. Vertebrate Skeletogenesis

Ve´ronique Lefebvre and Pallavi Bhattaram

9. The Molecular Regulation of Vertebrate Limb Patterning

Natalie C. Butterfield, Edwina McGlinn, and Carol Wicking

10. Eye Development

Jochen Graw