Mechanisms of Memory

This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader’s understanding.

More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples

1. Introduction - the basics of psychological learning and memory theory 2. Studies of human learning and memory 3. Non-associative learning and memory 4. Rodent behavioral learning and memory models 5. Associative learning and unlearning 6. Hippocampal Function in Cognition 7. Long-term Potentiation: A Candidate Cellular Mechanism for Information Storage in the CNS 8. The NMDA Receptor 9. Biochemical mechanisms for information storage at the cellular level 10. Molecular genetic mechanisms for long-term information storage at the cellular level 11. Inherited disorders of human memory – mental retardation syndromes 12. Aging-related memory disorders – Alzheimer’s Disease APPENDIX. The Basics of Experimental Design