G Protein-Coupled Receptors in Health and Disease, Part B

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

* This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

1. Diseased G protein-coupled receptors: An Introduction

Ya-Xiong Tao

2. GPR56 and its related diseases

Xianhua Piao and Ze Tian

3. GnRHR mutations and hypogonadotropic hypogonadism

Nicholas de Roux

4. LHR mutations and reproductive disorders

Deborah L. Segaloff

5. FSHR mutations and reproductive disorders

Ya-Xiong Tao and Deborah L. Segaloff

6. V2R mutations and nephrogenic diabetes insipidus

Daniel G. Bichet

7. Calcium-sensing receptor mutations

Geoffrey N. Hendy

8. Diseases caused by prostacyclin receptor mutations

John Hwa and Kathleen A Martin