Mouse Models of Developmental Genetic Disease

Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies.

* Provides busy clinical and basic science researchers a one-stop overview and synthesis of the latest research findings and contemporary thought in the area
* Allows researchers to compare and contrast disease models and also to learn about what models have been developed for large-scale distribution
* Allows researchers to evaluate basic differences in mouse and human biology and propose alternate pathways and possible gene interactions of the disease

1) Comprehensive Phenotyping of Genetically Modified Mice to Identify New Target Disease Indications
Author: Sandra Engle

2) Modeling the Repair Process in Multiple Sclerosis
Author: H. Arnett

3) Mouse Genetic Models for Individualized Symptomatology of Cancer and Infectious Disease
Author: P. Demant

4) New Rodent Models for Obesity, Diabetes, and Metabolic Syndrome
Author: R. Peterson

5) Mouse Models of Huntingdon’s Disease
Author: L. Menalled, M. Chesselet

6) Mouse Models for Ocular Disease
Author: L. Molday

7) Hyperlipidemia-Induced Atherosclerosis
Author: A. Daugherty

8) Mouse Models for Mitochondrial Disease
Authors: D. Wallace