Ciliary Function in Mammalian Development

Cilia--the tiny hairlike structures on the surface of cells—-have recently been identified as playing a role in a variety of disease and developmental disorders. Absent or defective cilia in certain cells can cause infertility, blindness, kidney disease, and lung disease. This volume presents recent findings in cilia research and current thought on the role of cilia in disease and developmental abnormalities.

1. Assembly and function of the basal body
Susan Dutcher
2. Cilia assembly and maintenance
Lotte Pedersen and Joel Rosenbaum
3. Origin and Evolution of the cilium
Peter Satir, David R. Mitchell, and Gaspar Jekely
4. Transport and targeting of ciliary proteins
Gregory Pazour and Robert Bloodgood
5. Tubulin Modifications and Regulation of Cilia formation and function
Jacek Gaertig
6. Ciliary functions in early embryo patterning and axis formation
Martina Brueckner
7. Cilia mediated control of Wnt signaling activity
Nicholas Katsanis
8. Ciliary function in regulating planar cell polarity of the inner ear
Ping Chen
9. Ciliary role in hedgehog signaling activity
Jeremy Reiter
10. Cilia regulation of cell migration during development and tissue repair
Soren Christensen
11. Cilia involvement in patterning and maintenance of bone
Rosa Serra and Courtney Haycraft
12. IFT in photoreceptor assembly and function
Joe Besharse
13. Ciliary dysfunction disease
Neeraj Sharma and Bradley Yoder