CNS Regeneration: Basic Science and Clinical Advances

This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury.

Incorporates information gained from cutting-edge photomicroscopy techniquesIncludes current information on clinical trialsPresents chapters on stem cells and other novel treatments for diseases of the CNS

Responses to Injury 1. Molecular and Genetic Responses to Injury Larry Benowitz 2. Glial Cells, Inflammation and CNS Trauma Michael T. Fitch and Jerry Silver

Stem Cells and Trophic Factors in CNS Repair 3. Stem Cell Therapy for Brain Tumors Rahul Jandial, Allen L. Ho, Michael L Levy and Evan Y. Snyder 4. Stem Cell Therapy for Parkinson's Disease Andreas Androutsellis-Theotokis, Maria A. Rueger and Ron D.G. McKay 5. Adult Neural Progenitor Cells in CNS Function and Disease Sebastian Jessberger, Stefan Aigner, James B. Aimone and Fred H. Gage 6. Neurotrophic Factors Mark Tuszynski

Novel Therapies for Parkinson’s and Huntington’s Disease 7. Direct Delivery of GDNF into the Non-human Primate and Human Parkinsonian Brain: Success and Road Blocks R. Grodin, Z. Zhang, Y. Ai, J. Slevin, A.B. Young, D.M. Gash and G.A. Gerhardt 8. Growth Factor Gene Therapy for Parkinon's Disease Jeffrey H. Kordower 9. Stimulating and Ablative Treatment for Parkinson's Disease Julie G. Pilitsis and Roy A.E. Bakay 10. Neurotrophic Factor and Stem Cell Therapy for Huntington's Disease Jeffrey H. Kordower

Novel Therapies for Alzheimer’s Disease 11. Neurotrophic Factors and Alzheimer's Disease Mark Tuszynski 12. Anti-amyloid-beta Immunotherapy as treatment for Alzheimmer’s Disease Joh R. Cirrito and David M. Holtzman

Novel Therapies for Spinal Cord Injury and White Matter Demyelination 13. Growth Factors for Spinal Cord Regeneration Mark Tuszynski 14. Modifying the Extracellular Matrix as a Treatment to Impove Functional Recovery After Spinal Cord Injury James W. Fawcett 15. Myelin Neutralization for Spinal Cord Injury and Stroke A.R. Walmsley, D. Bourikas and A.K. Mir 16. Strategies to Inhibit Signaling through Nogo Receptor 1 for Spinal Cord Injury and Stroke Jane K. Relton and Paul H. Weinreb 17. Cyclic AMP Modulation of Axonal Regeneration Following Spinal Cord Injury Sari S. Hanilla and marie T. Filbin 18. Multiple Sclerosis: Remyelination Jeffery D. Kocsis, Masanori Sasaki, Karen L Lankford and Christine Radtke

Design of Clinical Trials 19. Clinical Trials in Rehabilitation with Neural Repair Bruce H. Dobkin