The Mitochondrion in the Germline and Early Development

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

Includes many descriptive figuresTopics covered include the role of mitochondrial function, the use of ARTs to regulate mtDNA disease, nuclear transfer, and moreLatest volume in the series that covers 10 reviews from leading authorities in developmental biology

Section I. The mitochondrion and gametes
Chapter 1
The role of the mitochondrion in sperm function. Is there a place for oxidative phosphorylation or is this a purely glycolytic process?
Chapter 2
The role of mitochondrial function in the oocyte and embryo
Chapter 3
Mitochondrial DNA in the Oocyte and the developing embryo

Section II. Transmission
Chapter 4
Mitochondrial DNA and the mammalian oocyte
Chapter 5
Mitochondrial disease - its impact, aetiology and pathology
Chapter 6
Cybrid models of mtDNA disease and transmission, from cells to mice

Section III. The use of ARTs to regulate mtDNA disease.
Chapter 7
The use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNA
Chapter 8
Difficulties and possible solutions in the Genetic Management of mtDNA disease in the pre-implantation embryo

Section IV. The effects of invasive ARTs on mtDNA transmission
Chapter 9
Impact of assisted reproductive techniques: a mitochondrial perspective from the cytoplasmic transplantion
Chapter 10
Nuclear Transfer – preservation of a nuclear genome at the expense of its associated mtDNA genome(s)