Fundamentals of Preparative and Nonlinear Chromatography

The second edition of Fundamentals of Preparative and Nonlinear Chromatography is devoted to the fundamentals of a new process of purification or extraction of chemicals or proteins widely used in the pharmaceutical industry and in preparative chromatography. This process permits the preparation of extremely pure compounds satisfying the requests of the US Food and Drug Administration. The book describes the fundamentals of thermodynamics, mass transfer kinetics, and flow through porous media that are relevant to chromatography. It presents the models used in chromatography and their solutions, discusses the applications made, describes the different processes used, their numerous applications, and the methods of optimization of the experimental conditions of this process.

1. Introduction, Definitions, Goal
2. The Mass Balance Equation of Chromatography and Its General Properties
3. Single-Component Equilibrium Isotherms
4. Competitive Equilibrium Isotherms
5. Transfer Phenomena in Chromatography
6. Linear Chromatography
7. Band Profiles of Single-Components with the Ideal Model
8. Band Profiles of Two Components with the Ideal Model
9. Band Profiles in Displacement Chromatography with the Ideal Model
10. Single-­Component Profiles with the Equilibrium Dispersive Model
11. Two-Component Band Profiles with the Equilibrium-Dispersive Model
12. Frontal Analysis, Displacement and the Equilibrium-Dispersive Model
13. System Peaks with the Equilibrium-Dispersive Model
14. Kinetic Models and Single-Component Problems
15. Gradient Elution Chromatography under Nonlinear Conditions
16. Kinetic Models and Multicomponent Problems
17. Simulated Moving Bed Chromatography
18. Optimization of the Experimental Conditions