The Mouse in Biomedical Research: Immunology

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

1. The Molecular Basis of Lymphoid Architecture in the Mouse
2. The Biology of Toll-like Receptors in Mice
3. Genomic Organization of the Mouse Major Histocompatibility Complex
4. Some Biological Features of Dendritic Cells in the Mouse
5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
6. Mouse Natural Killer Cells: Function and Activation
7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
9. Mouse Models of Negative Selection
10. Peripheral Tolerance of T Cells in the Mouse
11. The Genetics of Mouse Models of Systemic Lupus
12. Inhibitory Receptors and Autoimmunity in the Mouse
13. Mouse Models of Immunodeficiency
14. Mouse Models to Study the Pathogenesis of Allergic Asthma
15. The Mouse Trap: How Well Do Mice Model Human Immunology?