Bone Disease of Organ Transplantation

Bone disease, particularly osteoporosis, has emerged as a common and serious complication of solid organ transplantation. In recent years there have been real advances in our understanding of the pathogenesis and pathophysiology of bone loss, however treatment studies have been relatively sparse and successful strategies to reduce skeletal morbidity after transplantation remain to be clearly established. Bone Disease of Organ Transplantation provides a unique resource for the many health professionals involved with transplantation of bone disease, both in terms of its scientific background and the management of the disease in clinical practice.

Basic Transplantation and Bone BiologyPathogenesis of Transplantation Related Bone DiseaseClinical Features of Transplantation Bone DiseaseManagement

Part I. Basic Transplantation and Bone Biology 1. Principles of Transplantation Immunology 2. Bone Biology: Bone Structure and Remodeling 3. Skeletal Effects of Glucocorticoids: Basic and Clinical Aspects 4. Transplantation Bone Disease Induced by Non-Steroid Immunosuppressants 5. Molecular Effects of Calcineurin Inhibitors 6. Bone and Immune System

Part II. Pathogenesis of Transplantation-Related Bone Disease 7. Fracture Prevalence and Incidence in Solid Organ Transplant Recipients 8. Bone Histomorphometry and Its Application to Transplantation Bone Disease 9. The Role of Parathyroid Hormone in the Evolution of Bone Loss After Organ Transplantation 10. The Role of Hypogonadism in the Evolution of Bone Loss Before and After Cardiac Transplantation 11. Pathogenesis of Transplantation Bone Diseases: A Unifying Hypothesis

Part III. Clinical Features of Transplantation Bone Disease 12. Bone Disease After Kidney Transplantation 13. Histologic Abnormalities of Bone Before and After Kidney Transplantation 14. Bone Disease Following Kidney-Pancreas and Pancreas Transplantation 15. Bone Disease After Liver Transplantation 16. Bone Disease in Patients Before and After Cardiac Transplantation 17. Bone Loss in Patients Before and After Lung Transplantation 18. Transplantation for Cystic Fibrosis: Effect on the Skeleton 19. Bone Diseaes After Bone Marrow Transplantation 20. Osteonecrosis and Organ Transplantation 21. Pediatric Transplant Bone Disease

Part IV. Management 22. Management of Bone Disease in Candidates for Organ Transplant 23. Management: Prevention of Bone Loss After Organ Transplantation 24. Management: Established Osteoporosis in Organ Transplant Receipients