Quinones and Quinone Enzymes, Part B

Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.

Mitochondrial Ubiquinone and ReductasesAnticancer Quinones and Quinone Oxido-ReductasesQuininone Reductases: Chemoprevention, NutritionQuinones and Age-Related Diseases

Section I: Mitochondrial Ubiquinone and Reductases

1: Mitochondrial Quinone Reductases: Complex I

2: Q-Cycle Bypass Reactions at the Q_o Site of the Cytochrome bc₁ (and Related) Complexes

3: Targeting Coenzyme Q Derivatives to Mitochondria

4: The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia

5: Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency

6: Coenzyme Q Cytoprotective Mechanisms

7: Dietary Coenzyme Q₁₀ and Mitochondrial Status

Section II: Anticancer Quinones and Quinone Oxidoreductases

8: NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics

9: Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)

10: Diaziridinylbenzoquinones

11: Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications

12: Bioactivation and Resistance to Mitomycin C

13: NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells

14: The “Prochaska” Microtiter Plate Bioassay for Inducers of NQO1

15: Structure-Activity Relationships in Two-Electron Reduction of Quinones

16: p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1

17: The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases

18: Induction of NQO1 in Cancer Cells

Section III: Quinone Reductases: Chemoprevention and Nutrition

19: Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates

20: Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase

21: Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens

22: Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes

23: Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

24: Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview

25: Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products From Dietary Broccoli

Section IV: Quinones and Age-Related Diseases

26: Therapeutic Effects of Coenzyme Q₁₀ in Neurodegenerative Diseases

27: Neuroprotective Actions of Coenzyme Q₁₀ in Parkinson's Disease

Author Index

Subject Index