Nuclear Receptors and Genetic Disease

Nuclear Receptors and Genetic Disease provides the first compilation of the role of nuclear hormones in health and disease and incorporates the latest breakthroughs in the field. It provides comprehensive reviews of the major receptors prepared by the acknowledged experts in each area. Each chapter provides information on the history, physiology, structure, mechanism of action, genetics, pathophysiology, disease diagnosis, and disease treatment for a particular nuclear receptor. Each chapter also includes a table showing all the known mutations of the respective nuclear receptor with the corresponding clinical disorder.

Receptors included in this book are:

The Nuclear Receptor SuperfamilyThyroid Hormone ReceptorsEstrogen and Progesterone ReceptorsThe Androgen ReceptorDAX-1 and Related Orphan ReceptorsThe Vitamin D ReceptorRetinoid ReceptorsMineralocorticoid and Glucocorticoid ReceptorsHepatocyte Nuclear Factor 4 αPeroxisome Proliferator Activated ReceptorsCoactivators and Corepressors

The Nuclear Receptor Superfamily, T.P. Burris
Thyroid Hormone Receptors, U. Dressel and A. Baniahmad
Estrogen and Progesterone Receptors, G.F. Allan
The Androgen Receptor, G. Jenster, J. Trapman and A.O. Brinkman
DAX-1 and Related Orphan Receptors, E. Vilain and E.R.B. McCabe
The Vitamin D Receptor, P.N. MacDonald, D.M. Kraichely and A.J. Brown
Retinoid Receptors, A.C.-K. Chung and A.J. Cooney
Mineralocorticoid and Glucocorticoid Receptors, T. Kino, A. Vottero and G.P. Chrousos
Hepatocyte Nuclear Factor 4α, F.M. Sladek and S.D. Seidel
Peroxisome Proliferator-Activated Receptors (PPAR), A. Elbrecht, A. Adams and D.E. Moller
Coactivators and Corepressors,D.M. Lonard and Z. Nawaz