The Flaviviruses: Structure, Replication and Evolution

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.

Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.

Includes new, detailed information on the evolution, viral structure and replication of the Flavivirus familyThe only complete reference book on a major virus familyDescibes the technologies that have contributed to our current knowledge about FlavivirusesIdentifies the major problems faced in understanding the virus-host interactions that result in disease

Taxonomy of the virus family Flaviviridae
Structure and replication
Molecular Biology of the Flaviviruses
Flavivirus Structure and Membrane Fusion
Kunjin RNA replication and applications of Kunjin replicons
Antigenic structure of flavivirus Proteins
5' and 3' non-coding regions in flavivirus RNA
Manipulation of Cell Surface Macromolecules by Flaviviruses
Flavivirus evolution
Origins, Evolution and vecto/host cp-adaptations within the genus Flavivirus
Microevolution and virulence of dengue viruses