HIV I: Molecular Biology and Pathogenesis: Clinical Applications

The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.
The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.

Detailed insights into viral packaging, expression, and assemblyMechanistic understanding of how HIV interacts with receptors and infects cellsDelineation of virally encoded regulatory processes unique to HIVClinical Applications: An updated review of current chemotherapeutics for HIVNew concepts in the discovery and design of novel anti-HIV drugsThe latest developments in HIV-vaccine research

HIV Therapeutics: Past, Present, and Future, O. Abu-Ata, J. Slim, G. Perez, and S.M. Smith.
HIV Drug Resistance and Viral Fitness, F. Clavel and F. Mammano.
Inhibitors of HIV-1 Reverse Transcriptase, M.A. Parniak and N. Sluis-Cremer.
HIV-I Protease: Maturation, Enzyme Specificity, and Drug Resistance, J.M. Louis, I.T. Weber, J. Tözsér, G.M. Clore, and A.M. Gronenborn.
HIV-I Integrase Inhibitors: Past, Present, and Future, N. Neamati, C. Marchand, and Y. Pommier.
Selection of HIV Replication Inhibitors: Chemistry and Biology, S. Hwang, N. Tamilarasu, and T.M. Rana.
Therapies Directed against the Rev Axis of HIV Autoregulation, A.I. Dayton and M.J. Zhang.
HIV-I Gene Therapy: Promise for the Future, R. Dornburg and R.J. Pomerantz.
Assessment of HIV Vaccine Development: Past, Present, and Future, M.W. Cho.
HIV-I-Associated Central Nervous System Dysfunction, F.C. Krebs, H. Ross, J. McAllister, and B. Wigdahl.
Molecular Mechanisms of Human Immunodeficiency Virus Type I Mother-Infact Transmission, N. Ahmad.
Molecular Epidemiology of HIV-I: An Example of Asia, M.-Y. Chen and C.-N. Lee.
Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment and Prevention, V.M. Hirsch and J.D. Lifson.
Animal Models for AIDS Pathogenesis, J.J. Trimble, J.R. Salkowitz, and H.W. Kestler.
Index.
Contents of Previous Volumes.