Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action

Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more.

This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries.

Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular levelExplores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseasesExamines the pharmacological findings on medicinal foods, including available clinical trials

Type-2 diabetes: Prevalence and significance 1. Type-2 diabetes: Definition, diagnosis and significance

Normal physiological control of carbohydrate and lipid metabolism and some common antidiabetic therapeutic targets 2. Glucose metabolism: Normal physiology, diabetic dysregulation, and therapeutic targets 3. Lipid metabolism: Normal physiology, dysregulation under obesity and diabetes, and therapeutic targets

Pathophysiology of type 2 diabetes and therapeutic options 4. Pathophysiology of type 2 diabetes complications 5. Current pharmacotherapy options for type 2 diabetes 6. Introduction to plant secondary metabolites—From biosynthesis to chemistry and antidiabetic action

Potential modulators of type-2 diabetes and associated diseases: Super fruits 7. Bilberries and blueberries as potential modulators of type 2 diabetes and associated diseases 8. The chemical and pharmacological basis of bitter melon (Momordica charantia L.) as a potential therapy for type 2 diabetes and obesity 9. The chemical and pharmacological basis of guava (Psidium guajava L.) as potential therapy for type 2 diabetes and associated diseases 10. The chemical and pharmacological basis of okra (Abelmoschus esculentus (L.) Moench) as potential therapy for type 2 diabetes 11. The chemical and pharmacological basis of papaya (Carica papaya L.) as potential therapy for type-2 diabetes and associated diseases 12. The chemical and pharmacological basis of pomegranate (Punica grantum L.) as potential therapy for type-2 diabetes and metabolic syndrome 13. The chemical and pharmacological basis of prickly pear cactus (Opuntia species) as potential therapy for type 2 diabetes and obesity 14. The chemical and pharmacological basis of pumpkins (Cucurbita species) as potential therapy for type-2 diabetes

Potential modulators of type-2 diabetes and associated diseases: Spices 15. The chemical and pharmacological basis of cinnamon (Cinnamomum species) as potential therapy for type-2 diabetes and associated diseases 16. The chemical and pharmacological basis of cloves (Syzygium aromaticum (L.) Merr. & L.M.Perry) as potential therapy for type 2 diabetes and associated diseases 17. The chemical and pharmacological basis of fenugreek (Trigonella foenum-graecum L.) as potential therapy for type 2 diabetes and associated diseases 18. The chemical and pharmacological basis of ginger (Zingiber officinale Roscoe) as potential therapy for diabetes and metabolic syndrome 19. The chemical and pharmacological basis of garlic (Allium sativum L.) as potential therapy for type 2 diabetes and metabolic syndrome 20. The chemical and pharmacological basis of turmeric (Curcuma longa L.) as potential therapy for type 2 diabetes and metabolic syndrome

Potential modulators of type 2 diabetes and associated diseases: Beverages, other foods, and herbal supplements 21. Chemical and pharmacological evidences for coffee as a modulator of type 2 diabetes and metabolic syndrome 22. The chemical and pharmacological basis of tea (Camellia sinensis (L.) Kuntze) as potential therapy for type 2 diabetes and metabolic syndrome 23. The chemical and pharmacological basis of rooibos (Aspalathus linearis (Burm. F.) R. Dahlgren) as potential therapy for type 2 diabetes and metabolic syndrome 24. The chemical and pharmacological basis of yerba mat