Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners.

Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done.

Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.

Presents state-of-the-art developments in organic synthesisProvides insight and offers new perspective to problem-solvingWritten by leading experts in the fieldUses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis

The Long and Winding Road of the Vinigrol Synthesis: a Learning Journey The Tetramic Acid Antibiotics a- and B-Lipomycin: Total Synthesis and Assignment of the Absolute Configuration of All Stereogenic Centers. Making Doubly Sure Step-Economical Synthesis of Clinprost and Analogues Utilizing a Novel Decarboxylation Reaction Total Symthesis of Aureothin (-)-Lyngbyaloside B, a Marine Macrolide Glycoside: Total Synthesis and Stereochemical Revision Total Synthesis of Ustiloxin D Stereoselective Synthesis of Isochromanones With and Without Activated Spin Intermediates: Total Synthesis of Ajudazol B The Total Synthesis of WU-07047; a Selective Inhibitor of Gα_q New Strategy Based on Sequential Michael/Aldol Reactions for the Asymmetric Synthesis of Cardenolides